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ave1642 antibody  (ImmunoGen Inc)

 
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    ImmunoGen Inc ave1642 antibody
    Ave1642 Antibody, supplied by ImmunoGen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ave1642/anti+igf+ir+monoclonal+antibody+huem164/pm37598440-311-23-15
    Average 90 stars, based on 1 article reviews
    ave1642 antibody - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    other:

    Article Title: Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets
    Article Snippet: , AVE1642 (ImmunoGen) , Hz IgG1 , Blocks IGF-1R , I (MM/NCT01233895 C) disc. .

    Article Title: Clinical development of inhibitors of the insulin-like growth factor receptor in oncology.
    Article Snippet: The insulin-like growth factor I receptor (IGF-IR) pathway plays a major role in cancer growth, tumor cell survival and resistance to therapy.. Ancillary evidence that targeting the IGF-IR may be useful in the treatment of cancer has been accumulating for almost two decades.. Today, more than two dozen compounds have been developed and clinical trials are underway for at least 12 of those.

    Article Title: Growth factor pathways in development and progression of hepatocellular carcinoma.
    Article Snippet: A study of AVE1642 in HCC (NCT00791544) (ImmunoGen MA, Waltham, SanofiAventis) was terminated due to a company decision to discontinue the drug development program, reportedly unrelated to safety or efficacy concerns.

    Article Title: Drugs targeting insulin-like growth factor 1 receptor
    Article Snippet: Drug Development phase Class Company Reference CP-751,871 Phase I–III Fully human monoclonal antibody Pfizer [62,67–69] MK-0646 Phase I Humanized monoclonal antibody Merck [70,71] AMG-479 Phase I and II Fully human monoclonal antibody Amgen [72–74] AVE1642 (humanized version of EM164) Phase I Humanized monoclonal antibody Immunogen and Sanofi-Aventis [64,78] IMC-A12 Phase I and II Fully human monoclonal antibody Imclone [61,76,77] BIIB022 Phase I Fully human monoclonal antibody Biogen [79] R1507 Phase II Fully human monoclonal antibody Roche [75] aIR3 Preclinical Murine monoclonal antibody [22,23] scFv-Fc Preclinical Chimeric single-chain antibody [65] EM164 Preclinical Murine monoclonal antibody Immunogen [64] h7C10 Preclinical Humanized monoclonal antibody Merck [63] 19D12 Preclinical Fully human monoclonal antibody Schering-Plough [66] INSM-18 Phase I/II Dual IGF1R/HER2 inhibitor Insmed http://www.insmed. com/oncology.php OSI-906 (close derivative of PQIP) Phase I Small molecule TKI OSI Pharmaceuticals [60] NVP-ADW742 Preclinical Small molecule TKI Novartis [50,51,94] NVP-AEW541 Preclinical Small molecule TKI Novartis [54,56–58] BMS-554417 Preclinical Small molecule dual (IGF1R/IR) TKI Bristol-Myers Squibb [52] BMS-536924 Preclinical Small molecule dual (IGF1R/IR) TKI Bristol-Myers Squibb [59] PPP (picropodophyllin) Preclinical Cyclolignan small molecule (non-ATP) competitive inihibitor Biovitrum [80] PQ 401 Preclinical Diaryl urea small molecule (non-ATP) inhibitor [81] TKI: tyrosine kinase inhibitor. tumor xenograft studies, with drugs including CP751,871, AVE1642, scFv-Fc, h7C10, A12, EM164 and 19D12 [61–66].

    Produced:

    Article Title: Anti-insulin growth factor receptor therapy in Ewing sarcoma
    Article Snippet: .. Human monoclonal anti-IGF-1R antibodies have been produced by many pharmaceutical companies: IMC-A12 (ImClone Systems, New York, NY, USA), AMG 479 (Amgen, Thousand Oaks, CA, USA), R1507 (Roche, Basel, Switzerland), CP-751,871 (Pfizer Inc, New York, NY, USA), SCH717454 (Schering-Plough Corporation, Kenilworth, NJ, USA), MK-0646 (Merck), and AVE1642 (ImmunoGen, Inc, Waltham, MA, USA/Sanofi-Aventis, Paris, France). ..



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    The 16 IGF-1R Inhibitors and the Estimated Number of Patients Entered Into Clinical Trials <xref ref-type= a " width="250" height="auto" />
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    Characteristics of antibodies directed to NLSAs.
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    anti-igf-1r neutralizing antibody ave1642  (ImmunoGen Inc)
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    A. CD99-induced cell death in parental or IGF-1R silenced TC-71 cells (Annexin V/PI) (upper panel). Results are represented as mean ± SEM of three independent experiments (*p<0.05, Student's t test). Western blotting evaluation of pan-RAS levels before (−) and after (+) treatment with 0662mAb in corresponding cells (lower panel). B. Vacuolization was assessed by Acridine Orange staining (AO) after 0662mAb treatment in parental (TC-71) or IGF-1R silenced cells (TC-siIGF1R#59) (scale bar 20μm). C. Experiments were performed in TC-71 cells before (−) and after (+) 15 min treatment with 0662mAb alone or in presence of either hAb <t>AVE1642</t> or NVP-AEW541 (Annexin V/PI). Histograms (upper left panel) represent mean percentage ± SEM of dead cells (*p<0.05, Student's t test); western blotting (upper right panel) evaluates pan-RAS levels in the same conditions. Lower panels display AO staining before (CTR) and after 3h treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541. For AO staining, cells were acquired using the microscope Nikon ECLIPSE 90i with Plan Fluor 40x/0.75 DIC M/N2. Pictures provided in the figures are all merged images.
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    anti-igf-1r drugs ave1642  (ImmunoGen Inc)
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    A. CD99-induced cell death in parental or IGF-1R silenced TC-71 cells (Annexin V/PI) (upper panel). Results are represented as mean ± SEM of three independent experiments (*p<0.05, Student's t test). Western blotting evaluation of pan-RAS levels before (−) and after (+) treatment with 0662mAb in corresponding cells (lower panel). B. Vacuolization was assessed by Acridine Orange staining (AO) after 0662mAb treatment in parental (TC-71) or IGF-1R silenced cells (TC-siIGF1R#59) (scale bar 20μm). C. Experiments were performed in TC-71 cells before (−) and after (+) 15 min treatment with 0662mAb alone or in presence of either hAb <t>AVE1642</t> or NVP-AEW541 (Annexin V/PI). Histograms (upper left panel) represent mean percentage ± SEM of dead cells (*p<0.05, Student's t test); western blotting (upper right panel) evaluates pan-RAS levels in the same conditions. Lower panels display AO staining before (CTR) and after 3h treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541. For AO staining, cells were acquired using the microscope Nikon ECLIPSE 90i with Plan Fluor 40x/0.75 DIC M/N2. Pictures provided in the figures are all merged images.
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    Image Search Results


    The 16 IGF-1R Inhibitors and the Estimated Number of Patients Entered Into Clinical Trials <xref ref-type= a " width="100%" height="100%">

    Journal: JAMA Network Open

    Article Title: Costs and Causes of Oncology Drug Attrition With the Example of Insulin-Like Growth Factor-1 Receptor Inhibitors

    doi: 10.1001/jamanetworkopen.2023.24977

    Figure Lengend Snippet: The 16 IGF-1R Inhibitors and the Estimated Number of Patients Entered Into Clinical Trials a

    Article Snippet: AVE1642 , Antibody , Sanofi-Aventis , 57.

    Techniques: Clinical Proteomics

    Activity of Single Agent IGF-1R Inhibitors on a Selection of Tumor Xenograft Models

    Journal: JAMA Network Open

    Article Title: Costs and Causes of Oncology Drug Attrition With the Example of Insulin-Like Growth Factor-1 Receptor Inhibitors

    doi: 10.1001/jamanetworkopen.2023.24977

    Figure Lengend Snippet: Activity of Single Agent IGF-1R Inhibitors on a Selection of Tumor Xenograft Models

    Article Snippet: AVE1642 , Antibody , Sanofi-Aventis , 57.

    Techniques: Activity Assay, Selection, Inhibition

    Characteristics of antibodies directed to NLSAs.

    Journal: Frontiers in Immunology

    Article Title: Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets

    doi: 10.3389/fimmu.2017.01936

    Figure Lengend Snippet: Characteristics of antibodies directed to NLSAs.

    Article Snippet: , AVE1642 (ImmunoGen) , Hz IgG1 , Blocks IGF-1R , I (MM/NCT01233895 C) disc. .

    Techniques:

    A. CD99-induced cell death in parental or IGF-1R silenced TC-71 cells (Annexin V/PI) (upper panel). Results are represented as mean ± SEM of three independent experiments (*p<0.05, Student's t test). Western blotting evaluation of pan-RAS levels before (−) and after (+) treatment with 0662mAb in corresponding cells (lower panel). B. Vacuolization was assessed by Acridine Orange staining (AO) after 0662mAb treatment in parental (TC-71) or IGF-1R silenced cells (TC-siIGF1R#59) (scale bar 20μm). C. Experiments were performed in TC-71 cells before (−) and after (+) 15 min treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541 (Annexin V/PI). Histograms (upper left panel) represent mean percentage ± SEM of dead cells (*p<0.05, Student's t test); western blotting (upper right panel) evaluates pan-RAS levels in the same conditions. Lower panels display AO staining before (CTR) and after 3h treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541. For AO staining, cells were acquired using the microscope Nikon ECLIPSE 90i with Plan Fluor 40x/0.75 DIC M/N2. Pictures provided in the figures are all merged images.

    Journal: Oncotarget

    Article Title: CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

    doi: 10.18632/oncotarget.13160

    Figure Lengend Snippet: A. CD99-induced cell death in parental or IGF-1R silenced TC-71 cells (Annexin V/PI) (upper panel). Results are represented as mean ± SEM of three independent experiments (*p<0.05, Student's t test). Western blotting evaluation of pan-RAS levels before (−) and after (+) treatment with 0662mAb in corresponding cells (lower panel). B. Vacuolization was assessed by Acridine Orange staining (AO) after 0662mAb treatment in parental (TC-71) or IGF-1R silenced cells (TC-siIGF1R#59) (scale bar 20μm). C. Experiments were performed in TC-71 cells before (−) and after (+) 15 min treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541 (Annexin V/PI). Histograms (upper left panel) represent mean percentage ± SEM of dead cells (*p<0.05, Student's t test); western blotting (upper right panel) evaluates pan-RAS levels in the same conditions. Lower panels display AO staining before (CTR) and after 3h treatment with 0662mAb alone or in presence of either hAb AVE1642 or NVP-AEW541. For AO staining, cells were acquired using the microscope Nikon ECLIPSE 90i with Plan Fluor 40x/0.75 DIC M/N2. Pictures provided in the figures are all merged images.

    Article Snippet: The following inhibitors were used alone or in combination with 0662mAb: necrostatin-1 (50μM), 3-methyladenine (3-MA) (5mM, Sigma), Cytochalasin D (5μg/ml, Sigma) pre-treatment at 37°C for 60 min, chlorpromazine (10μg/ml, Sigma) pretreatment at 37°C for 30 min, anti-IGF-1R neutralizing antibody AVE1642 [ ] (100ng/ml, kindly provided by ImmunoGen Inc), tyrosine kinase inhibitor NVP-AEW541 (1μM, kindly provided by Novartis) pre-treatment at 37°C for 60 min.

    Techniques: Western Blot, Staining, Microscopy